Using this method to relieve constipation can have you running to the bathroom for several hours, so it's way more comfortable to just stay home.Īugust 26, - That's a really good point. I agree that when using an enema suppository or a homemade enema, you should definitely stay near a toilet. That way, you'll have a bowel movement in the morning, usually right after you wake up. It's also best to take laxatives in the evening too, if you're going to use laxatives in combination with an enema suppository. That way you can worry about getting everything cleaned out, rather than looking for the nearest bathroom. I think the best time to use an enema suppository is in the evening, when you know you don't have anywhere else to go.